PUBLICATIONS AND AWARDS
Revealing hyperactivated IFN-γ pathways in perianal fistulizing Crohn's disease using single-cell and spatial multi-omics.
Cao S, Nguyen KM, Ma K, Tan T, Yao X, Liu TC, Ayoub M, Devi J, Samaan S, Liu Y, Smith R, Silviera ML, Hunt SR, Wise PE, Mutch MG, Glasgow SC, Chapman WC Jr, Cowan ML, Ciorba MA, Colonna M, Deepak P; SPARC IBD Investigators. J Clin Invest. 2025 Jul 3;135(17):e193413. doi: 10.1172/JCI193413. eCollection 2025 Sep 2.
PMID: 40608410
Safety and Clinical Effectiveness of GLP1 Receptor Agonists in Inflammatory Bowel Disease Patients.
Sehgal P, Lewis JD, Pickett-Blakely O, Nandi N, Bewtra M, Lichtenstein GR. Clin Gastroenterol Hepatol. 2025 Jul;23(8):1453-1454.e3. doi: 10.1016/j.cgh.2024.12.017. Epub 2025 Jan 30.
PMID: 39892632
Durable Immune Response and Long-term Efficacy of COVID-19 Vaccination in Children With Inflammatory Bowel Disease.
Kastl AJ, Brenner EJ, Weaver KN, Zhang X, Strople JA, Adler J, Dubinsky MC, Bousvaros A, Watkins R, Dai X, Chen W, Cross RK, Higgins PDR, Ungaro RC, Bewtra M, Bellaguarda EA, Farraye FA, Chun KY, Zikry M, Bastidas M, Firestine AM, Craig RG, Boccieri ME, Long MD, Kappelman MD. Inflamm Bowel Dis. 2025 Jul 7;31(7):1797-1805. doi: 10.1093/ibd/izae225.
PMID: 39412147
Correlation Between Serum and Fecal Biomarkers and Patient-Reported Outcomes in Patients with Crohn's Disease and Ulcerative Colitis.
Motwani KK, Alizadeh M, Abutaleb A, Grossman J, Wellington J, Cross RK; SPARC-IBD investigators. Dig Dis Sci. 2024 Jun;69(6):2154-2163. doi: 10.1007/s10620-024-08421- w. Epub 2024 Apr 5.
PMID: 38580888
Surgery for Crohn's Disease Is Associated With a Dysbiotic Microbiome and Metabolome: Results From Two Prospective Cohorts. Lewis JD, Daniel SG, Li H, Hao F, Patterson AD, Hecht AL, Brensinger CM, Wu GD, Bittinger K; DINE-CD; SPARC IBD Investigators. Cell Mol Gastroenterol Hepatol. 2024;18(3):101357. doi: 10.1016/j.jcmgh.2024.05.005. Epub 2024 May 14.
PMID: 38750900
Long-Term Effectiveness and Durability of COVID-19 Vaccination Among Patients With Inflammatory Bowel Disease.
Brenner EJ, Weaver KN, Zhang X, Kastl AJ, Strople JA, Adler J, Dubinsky MC, Bousvaros A, Watkins R, Dai X, Chen W, Cross RK, Higgins PDR, Ungaro RC, Bewtra M, Bellaguarda EA, Farraye FA, Chun KY, Zikry M, Bastidas M, Firestine A, Craig RG, Boccieri ME, Long MD, Kappelman MD. Clin Gastroenterol Hepatol. 2024 Jul;22(7):1475-1486.e4. doi: 10.1016/j.cgh.2024.02.001. Epub 2024 Feb 17. PMID: 38369224
Humoral immune response and safety of SARS-CoV-2 vaccination in very early onset inflammatory bowel disease.
Kastl AJ, Weaver KN, Zhang X, Strople JA, Adler J, Kelsen JR, Dubinsky MC, Bousvaros A, Watkins R, Dai C, Cross RK, Higgins PDR, Ungaro R, Bewtra M, Bellaguarda EA, Farraye FA, Chun K, Zikry M, Bastidas M, Boccieri ME, Firestine A, Long MD, Kappelman MD. J Pediatr Gastroenterol Nutr. 2024 Apr;78(4):871-877. doi: 10.1002/jpn3.12142. Epub 2024 Feb 14.
PMID: 38356293
Factors Associated With Extraintestinal Manifestations of Inflammatory Bowel Disease in SPARC-IBD.
Alizadeh M, Motwani K, Siaton BC, Abutaleb A, Ravel J, Cross RK; SPARCIBD Investigators. Inflamm Bowel Dis. 2024 Nov 4;30(11):2027-2036. doi: 10.1093/ibd/izad280.
PMID: 38102817
A Practical Guide to the Use of Upadacitinib in Ulcerative Colitis and Crohn's Disease.
Weiss A, Barnes EL, Bewtra M. Am J Gastroenterol. 2024 Jul;119(7):1211-1217. doi: 10.14309/ajg.0000000000002598. Epub 2024 Jan 22.
PMID: 38047577
Pediatric Cholelithiasis in the United States: National Hospitalization Trends, 2006 to 2019.
Agawu A, Kanagawa C, Wong J, Shults J, Feudtner C, Bewtra M. J Pediatr Gastroenterol Nutr. 2023 Dec 1;77(6):741-747. doi: 10.1097/MPG.0000000000003959. Epub 2023 Sep 26.
PMID: 37755879
Isolation of Epithelial and Stromal Cells from Colon Tissues in Homeostasis and Under Inflammatory Conditions.
Morral C, Ghinnagow R, Karakasheva T, Zhou Y, Thadi A, Li N, Yoshor B, Soto GE, Chen CH, Aleynick D, Weinbrom S, Fulton M, Uzun Y, Bewtra M, Kelsen JR, Lengner CJ, Tan K, Minn AJ, Hamilton KE. Bio Protoc. 2023 Sep 20;13(18):e4825. doi: 10.21769/BioProtoc.4825. eCollection 2023 Sep 20.
PMID: 37753470
Yield of Serial Testing for Tuberculosis Exposure in Patients With Inflammatory Bowel Diseases: One Test is Not Enough.
Lapp SL, Bewtra M, Lewis JD; SPARC IBD Investigators. Clin Gastroenterol Hepatol. 2024 Feb;22(2):420-422.e2. doi: 10.1016/j.cgh.2023.06.003. Epub 2023 Jun 17.
PMID: 37331412
The enteric nervous system relays psychological stress to intestinal inflammation.
Schneider KM, Blank N, Alvarez Y, Thum K, Lundgren P, Litichevskiy L, Sleeman M, Bahnsen K, Kim J, Kardo S, Patel S, Dohnalová L, Uhr GT, Descamps HC, Kircher S, McSween AM, Ardabili AR, Nemec KM, Jimenez MT, Glotfelty LG, Eisenberg JD, Furth EE, Henao-Mejia J, Bennett FC, Pierik MJ, Romberg-Camps M, Mujagic Z, Prinz M, Schneider CV, Wherry EJ, Bewtra M, Heuckeroth RO, Levy M, Thaiss CA. Cell. 2023 Jun 22;186(13):2823-2838.e20. doi: 10.1016/j.cell.2023.05.001. Epub 2023 May 25.
PMID: 37236193
Utilization of Treat-to-Target Monitoring Colonoscopy After Treatment Initiation in the US-Based Study of a Prospective Adult Research Cohort With Inflammatory Bowel Disease.
Yang JY, Lund JL, Funk MJ, Hudgens MG, Lewis JD, Kappelman MD; SPARC IBD Investigators. Am J Gastroenterol. 2023 Sep 1;118(9):1638-1647. doi: 10.14309/ajg.0000000000002294. Epub 2023 Apr 13. PMID: 37053548
Humoral Immune Response and Safety of SARS-CoV-2 Vaccination in Pediatric Inflammatory Bowel Disease.
Kastl AJ, Weaver KN, Zhang X, Strople JA, Adler J, Dubinsky MC, Bousvaros A, Watkins R, Dai X, Chen W, Cross RK, Higgins PDR, Ungaro RC, Bewtra M, Bellaguarda EA, Farraye FA, Chun KY, Zikry M, Fernando M, Bastidas M, Hernandez CG, Craig RG, Boccieri ME, Firestine A, Long MD, Kappelman MD. Am J Gastroenterol. 2023 Jan 1;118(1):129-137. doi: 10.14309/ajg.0000000000002016. Epub 2022 Sep 16.
PMID: 36114773
The miR-181 family regulates colonic inflammation through its activity in the intestinal epithelium. Jimenez MT, Clark ML, Wright JM, Michieletto MF, Liu S, Erickson I, Dohnalova L, Uhr GT, Tello-Cajiao J, Joannas L, Williams A, Gagliani N, Bewtra M, Tomov VT, Thaiss CA, Henao-Mejia J. J Exp Med. 2022 Dec 5;219(12):e20212278. doi: 10.1084/jem.20212278. Epub 2022 Sep 8.
PMID: 36074090
Low Rates of Breakthrough COVID-19 Infection After SARS-CoV-2 Vaccination in Patients With Inflammatory Bowel Disease.
Weaver KN, Zhang X, Dai X, Chen W, Watkins R, Adler J, Dubinsky MC, Kastl A, Bousvaros A, Strople JA, Cross RK, Higgins PDR, Ungaro RC, Bewtra M, Bellaguarda E, Farraye FA, Craig R, Hernandez C, Boccieri ME, Firestine A, Chun KY, Long MD, Kappelman MD. Inflamm Bowel Dis. 2023 Mar 1;29(3):483-486. doi: 10.1093/ibd/izac138.
PMID: 35830416
High-dimensional profiling reveals Tc17 cell enrichment in active Crohn's disease and identifies a potentially targetable signature.
Globig AM, Hipp AV, Otto-Mora P, Heeg M, Mayer LS, Ehl S, Schwacha H, Bewtra M, Tomov V, Thimme R, Hasselblatt P, Bengsch B. Nat Commun. 2022 Jun 27;13(1):3688. doi: 10.1038/s41467-022-31229-z.
PMID: 35760777
Strong Response to SARS-CoV-2 Vaccine Additional Doses Among Patients With Inflammatory Bowel Diseases. Long MD, Weaver KN, Zhang X, Chun K, Kappelman MD; PREVENTCOVID Study Group. Clin Gastroenterol Hepatol. 2022 Aug;20(8):1881-1883.e1. doi: 10.1016/j.cgh.2022.01.056. Epub 2022 Feb 9.
PMID: 35150924
Factors Affecting Initial Humoral Immune Response to SARS-CoV-2 Vaccines Among Patients With Inflammatory Bowel Diseases.
Kappelman MD, Weaver KN, Zhang X, Dai X, Watkins R, Adler J, Dubinsky MC, Kastl A, Bousvaros A, Strople JA, Cross RK, Higgins PDR, Ungaro RC, Bewtra M, Bellaguarda EA, Farraye FA, Boccieri ME, Firestine A, Chun KY, Fernando M, Bastidas M, Zikry M, Long MD. Am J Gastroenterol. 2022 Mar 1;117(3):462-469. doi: 10.14309/ajg.0000000000001619.
PMID: 35029167
Impact of SARS-CoV-2 Vaccination on Inflammatory Bowel Disease Activity and Development of Vaccine-Related Adverse Events: Results From PREVENT-COVID.
Weaver KN, Zhang X, Dai X, Watkins R, Adler J, Dubinsky MC, Kastl A, Bousvaros A, Strople JA, Cross RK, Higgins PDR, Ungaro RC, Bewtra M, Bellaguarda E, Farraye FA, Boccieri ME, Firestine A, Kappelman MD, Long MD. Inflamm Bowel Dis. 2022 Oct 3;28(10):1497-1505. doi: 10.1093/ibd/izab302.
PMID: 34871388
Women's Willingness to Accept Risks of Medication for Inflammatory Bowel Disease During Pregnancy.
Kushner T, Fairchild A, Johnson FR, Sands BE, Mahadevan U, Subramanian S, Ananthakrishnan A, Ha C, Bewtra M. Patient. 2022 May;15(3):353-365. doi: 10.1007/s40271-021-00561-9. Epub 2021 Nov 9. PMID: 34750784
The Development and Initial Findings of A Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease (SPARC IBD).
Raffals LE, Saha S, Bewtra M, Norris C, Dobes A, Heller C, O'Charoen S, Fehlmann T, Sweeney S, Weaver A, Bishu S, Cross R, Dassopoulos T, 9/3/25, 1:00 PM Clipboard - PubMed https://pubmed.ncbi.nlm.nih.gov/clipboard/ 7/14 Fischer M, Yarur A, Hudesman D, Parakkal D, Duerr R, Caldera F, Korzenik J, Pekow J, Wells K, Bohm M, Perera L, Kaur M, Ciorba M, Snapper S, Scoville EA, Dalal S, Wong U, Lewis JD. Inflamm Bowel Dis. 2022 Feb 1;28(2):192-199. doi: 10.1093/ibd/izab071. PMID: 34436563
Humoral Immune Response to Messenger RNA COVID19 Vaccines Among Patients With Inflammatory Bowel Disease.
Kappelman MD, Weaver KN, Boccieri M, Firestine A, Zhang X, Long MD; PREVENT-COVID Study Group. Gastroenterology. 2021 Oct;161(4):1340-1343.e2. doi: 10.1053/j.gastro.2021.06.016. Epub 2021 Jun 15.
PMID: 34144046
The Impact of Introducing Patient-Reported Inflammatory Bowel Disease Symptoms via Electronic Survey on Clinic Visit Length, Patient and Provider Satisfaction, and the Environment Microbiome.
Roy Paladhi U, Harb AH, Daniel SG, Dawwas GK, Schnellinger EM, Wollack C, Aberra FN, Bewtra M, Green JA, Klaproth JA, Lichtenstein GR, Saxena A, Berera S, Buchner A, Mehta SJ, Osterman MT, Rashid F, Tomov V, Caldera F, Sumona S, Mahadevan U, Roy A, Nessel L, Wu GD, Bittinger K, Lewis JD. Inflamm Bowel Dis. 2021 Apr 15;27(5):746-750. doi: 10.1093/ibd/izaa356.
PMID: 33452800
Norovirus-Specific CD8 T Cell Responses in Human Blood and Tissues.
Pattekar A, Mayer LS, Lau CW, Liu C, Palko O, Bewtra M, Consortium H, Lindesmith LC, Brewer-Jensen PD, Baric RS, Betts MR, Naji A, Wherry EJ, Tomov VT. Cell Mol Gastroenterol Hepatol. 2021;11(5):1267-1289. doi: 10.1016/j.jcmgh.2020.12.012. Epub 2021 Jan 11.
PMID: 33444817
Support Tools for Preference-Sensitive Decisions in Healthcare: Where Are We? Where Do We Go? How Do We Get There?
Ostermann J, Brown DS, van Til JA, Bansback N, Légaré F, Marshall DA, Bewtra M. Patient. 2019 Oct;12(5):439-443. doi: 10.1007/s40271-019-00372-z.
PMID: 31256346
Comparing the Noncomparable: The Need for Equivalence Measures That Make Sense in HealthEconomic Evaluations.
Johnson FR, Scott FI, Reed SD, Lewis JD, Bewtra M. Value Health. 2019 Jun;22(6):684-692. doi: 10.1016/j.jval.2019.03.011. Epub 2019 May 17.
PMID: 31198186
Variation Among Patients With Crohn's Disease in Benefit vs Risk Preferences and Remission Time Equivalents.
Bewtra M, Reed SD, Johnson FR, Scott FI, Gilroy E, Sandler RS, Chen W, Lewis JD. Clin Gastroenterol Hepatol. 2020 Feb;18(2):406-414.e7. doi: 10.1016/j.cgh.2019.05.010. Epub 2019 May 14.
PMID: 31100456
Improved Quality of Life With Anti-TNF Therapy Compared With Continued Corticosteroid Utilization in Crohn's Disease. Scott FI, Johnson FR, Bewtra M, Brensinger CM, Roy JA, Reed SD, Osterman MT, Mamtani R, Chen L, Yun H, Xie F, Curtis JR, Lewis JD. Inflamm Bowel Dis. 2019 Apr 11;25(5):925-936. doi: 10.1093/ibd/izy321.
PMID: 30535149
Anti-TNF Drugs versus Long-Term Steroid Use for Patients with Inflammatory Bowel Diseases [Internet].
Lewis JD, Bewtra M, Scott FI, Brensinger CM, Reed SD, Roy JA, Osterman MT, Mamtani R, Chen L, Yun H, Xie F, Gilroy E, Sandler RS, Chen W, Curtis JR, Johnson FR. Washington (DC): Patient-Centered Outcomes Research Institute (PCORI); 2018 Nov.
PMID: 37428852
High-dimensional immune phenotyping and transcriptional analyses reveal robust recovery of viable human immune and epithelial cells from frozen gastrointestinal tissue.
Konnikova L, Boschetti G, Rahman A, Mitsialis V, Lord J, Richmond C, Tomov VT, Gordon W, Jelinsky S, Canavan J, Liss A, Wall S, Field M, Zhou F, Goldsmith JD, Bewtra M, Breault DT, Merad M, Snapper SB. Mucosal Immunol. 2018 Nov;11(6):1684-1693. doi: 10.1038/s41385-018- 0047-y. Epub 2018 Aug 15.
PMID: 30111863
State of Adult Trainee Inflammatory Bowel Disease Education in the United States: A National Survey.
Cohen BL, Ha C, Ananthakrishnan AN, Rieder F, Bewtra M. Inflamm Bowel Dis. 2016 Jul;22(7):1609-15. doi: 10.1097/MIB.0000000000000766.
PMID: 27306068
Rising Educators, Academicians, and Clinicians Helping Inflammatory Bowel Disease (REACH-IBD)-Promoting Improvement of Inflammatory Bowel Disease Education in the United States.
Rieder F, Cohen BL, Dotson JL, Bewtra M, Ananthakrishnan AN, Falaiye TO, Ha CY. Inflamm Bowel Dis. 2016 Jun;22(6):1531-2. doi: 10.1097/MIB.0000000000000814.
PMID: 27167574 Free PMC article.
Patients with Ulcerative Colitis Are More Concerned About Complications of Their Disease than Side Effects of Medications.
Thompson KD, Connor SJ, Walls DM, Gollins J, Stewart SK, Bewtra M, Baumblatt GL, Holubar SD, Greenup AJ, Sechi A, Girgis A, Rubin DT, Siegel CA. Inflamm Bowel Dis. 2016 Apr;22(4):940-7. doi: 10.1097/MIB.0000000000000740.
PMID: 26950308
Inflammatory Bowel Disease Patients' Willingness to Accept Medication Risk to Avoid Future Disease Relapse. Bewtra M, Fairchild AO, Gilroy E, Leiman DA, Kerner C, Johnson FR, Lewis JD. Am J Gastroenterol. 2015 Dec;110(12):1675-81. doi: 10.1038/ajg.2015.321. Epub 2015 Oct 20.
PMID: 26482859
Mortality associated with medical therapy versus elective colectomy in ulcerative colitis: a cohort study.
Bewtra M, Newcomb CW, Wu Q, Chen L, Xie F, Roy JA, Aarons CB, Osterman MT, Forde KA, Curtis JR, Lewis JD. Ann Intern Med. 2015 Aug 18;163(4):262-70. doi: 10.7326/M14-0960.
PMID: 26168366
An optimized patient-reported ulcerative colitis disease activity measure derived from the Mayo Score and the Simple Clinical Colitis Activity Index.
Bewtra M. Inflamm Bowel Dis. 2015 Jan;21(1):E1. doi: 10.1097/MIB.0000000000000256.
PMID: 25479459
The benefit-to-risk balance of combining infliximab with azathioprine varies with age: a markov model.
Scott FI, Vajravelu RK, Bewtra M, Mamtani R, Lee D, Goldberg DS, Lewis JD. Clin Gastroenterol Hepatol. 2015 Feb;13(2):302-309.e11. doi: 10.1016/j.cgh.2014.07.058. Epub 2014 Aug 10.
PMID: 25117775
An optimized patient-reported ulcerative colitis disease activity measure derived from the Mayo score and the simple clinical colitis activity index.
Bewtra M, Brensinger CM, Tomov VT, Hoang TB, Sokach CE, Siegel CA, Lewis JD. Inflamm Bowel Dis. 2014 Jun;20(6):1070-8. doi: 10.1097/MIB.0000000000000053.
PMID: 24810138
Patient preferences for surgical versus medical therapy for ulcerative colitis.
Bewtra M, Kilambi V, Fairchild AO, Siegel CA, Lewis JD, Johnson FR. Inflamm Bowel Dis. 2014 Jan;20(1):103-14. doi: 10.1097/01.MIB.0000437498.14804.50.
PMID: 24280881
Histone deacetylase 3 coordinates commensal-bacteriadependent intestinal homeostasis.
Alenghat T, Osborne LC, Saenz SA, Kobuley D, Ziegler CG, Mullican SE, Choi I, Grunberg S, Sinha R, Wynosky-Dolfi M, Snyder A, Giacomin PR, Joyce KL, Hoang TB, Bewtra M, Brodsky IE, Sonnenberg GF, Bushman FD, Won KJ, Lazar MA, Artis D. Nature. 2013 Dec 5;504(7478):153-7. doi: 10.1038/nature12687. Epub 2013 Nov 3.
PMID: 24185009
Assessing patient preferences for treatment options and process of care in inflammatory bowel disease: a critical review of quantitative data.
Bewtra M, Johnson FR. Patient. 2013;6(4):241-55. doi: 10.1007/s40271-013-0031-2.
PMID: 24127239
Crohn's disease and ulcerative colitis are associated with elevated standardized mortality ratios: a meta-analysis. Bewtra M, Kaiser LM, TenHave T, Lewis JD. Inflamm Bowel Dis. 2013 Mar;19(3):599-613. doi: 10.1097/MIB.0b013e31827f27ae.
PMID: 23388544
Trends in hospitalization rates for inflammatory bowel disease in the United States. Bewtra M, Su C, Lewis JD. Clin Gastroenterol Hepatol. 2007 May;5(5):597-601. doi: 10.1016/j.cgh.2007.01.015. Epub 2007 Mar 26.
PMID: 17382602
Cao S, Nguyen KM, Ma K, Tan T, Yao X, Liu TC, Ayoub M, Devi J, Samaan S, Liu Y, Smith R, Silviera ML, Hunt SR, Wise PE, Mutch MG, Glasgow SC, Chapman WC Jr, Cowan ML, Ciorba MA, Colonna M, Deepak P; SPARC IBD Investigators. J Clin Invest. 2025 Jul 3;135(17):e193413. doi: 10.1172/JCI193413. eCollection 2025 Sep 2.
PMID: 40608410
Safety and Clinical Effectiveness of GLP1 Receptor Agonists in Inflammatory Bowel Disease Patients.
Sehgal P, Lewis JD, Pickett-Blakely O, Nandi N, Bewtra M, Lichtenstein GR. Clin Gastroenterol Hepatol. 2025 Jul;23(8):1453-1454.e3. doi: 10.1016/j.cgh.2024.12.017. Epub 2025 Jan 30.
PMID: 39892632
Durable Immune Response and Long-term Efficacy of COVID-19 Vaccination in Children With Inflammatory Bowel Disease.
Kastl AJ, Brenner EJ, Weaver KN, Zhang X, Strople JA, Adler J, Dubinsky MC, Bousvaros A, Watkins R, Dai X, Chen W, Cross RK, Higgins PDR, Ungaro RC, Bewtra M, Bellaguarda EA, Farraye FA, Chun KY, Zikry M, Bastidas M, Firestine AM, Craig RG, Boccieri ME, Long MD, Kappelman MD. Inflamm Bowel Dis. 2025 Jul 7;31(7):1797-1805. doi: 10.1093/ibd/izae225.
PMID: 39412147
Correlation Between Serum and Fecal Biomarkers and Patient-Reported Outcomes in Patients with Crohn's Disease and Ulcerative Colitis.
Motwani KK, Alizadeh M, Abutaleb A, Grossman J, Wellington J, Cross RK; SPARC-IBD investigators. Dig Dis Sci. 2024 Jun;69(6):2154-2163. doi: 10.1007/s10620-024-08421- w. Epub 2024 Apr 5.
PMID: 38580888
Surgery for Crohn's Disease Is Associated With a Dysbiotic Microbiome and Metabolome: Results From Two Prospective Cohorts. Lewis JD, Daniel SG, Li H, Hao F, Patterson AD, Hecht AL, Brensinger CM, Wu GD, Bittinger K; DINE-CD; SPARC IBD Investigators. Cell Mol Gastroenterol Hepatol. 2024;18(3):101357. doi: 10.1016/j.jcmgh.2024.05.005. Epub 2024 May 14.
PMID: 38750900
Long-Term Effectiveness and Durability of COVID-19 Vaccination Among Patients With Inflammatory Bowel Disease.
Brenner EJ, Weaver KN, Zhang X, Kastl AJ, Strople JA, Adler J, Dubinsky MC, Bousvaros A, Watkins R, Dai X, Chen W, Cross RK, Higgins PDR, Ungaro RC, Bewtra M, Bellaguarda EA, Farraye FA, Chun KY, Zikry M, Bastidas M, Firestine A, Craig RG, Boccieri ME, Long MD, Kappelman MD. Clin Gastroenterol Hepatol. 2024 Jul;22(7):1475-1486.e4. doi: 10.1016/j.cgh.2024.02.001. Epub 2024 Feb 17. PMID: 38369224
Humoral immune response and safety of SARS-CoV-2 vaccination in very early onset inflammatory bowel disease.
Kastl AJ, Weaver KN, Zhang X, Strople JA, Adler J, Kelsen JR, Dubinsky MC, Bousvaros A, Watkins R, Dai C, Cross RK, Higgins PDR, Ungaro R, Bewtra M, Bellaguarda EA, Farraye FA, Chun K, Zikry M, Bastidas M, Boccieri ME, Firestine A, Long MD, Kappelman MD. J Pediatr Gastroenterol Nutr. 2024 Apr;78(4):871-877. doi: 10.1002/jpn3.12142. Epub 2024 Feb 14.
PMID: 38356293
Factors Associated With Extraintestinal Manifestations of Inflammatory Bowel Disease in SPARC-IBD.
Alizadeh M, Motwani K, Siaton BC, Abutaleb A, Ravel J, Cross RK; SPARCIBD Investigators. Inflamm Bowel Dis. 2024 Nov 4;30(11):2027-2036. doi: 10.1093/ibd/izad280.
PMID: 38102817
A Practical Guide to the Use of Upadacitinib in Ulcerative Colitis and Crohn's Disease.
Weiss A, Barnes EL, Bewtra M. Am J Gastroenterol. 2024 Jul;119(7):1211-1217. doi: 10.14309/ajg.0000000000002598. Epub 2024 Jan 22.
PMID: 38047577
Pediatric Cholelithiasis in the United States: National Hospitalization Trends, 2006 to 2019.
Agawu A, Kanagawa C, Wong J, Shults J, Feudtner C, Bewtra M. J Pediatr Gastroenterol Nutr. 2023 Dec 1;77(6):741-747. doi: 10.1097/MPG.0000000000003959. Epub 2023 Sep 26.
PMID: 37755879
Isolation of Epithelial and Stromal Cells from Colon Tissues in Homeostasis and Under Inflammatory Conditions.
Morral C, Ghinnagow R, Karakasheva T, Zhou Y, Thadi A, Li N, Yoshor B, Soto GE, Chen CH, Aleynick D, Weinbrom S, Fulton M, Uzun Y, Bewtra M, Kelsen JR, Lengner CJ, Tan K, Minn AJ, Hamilton KE. Bio Protoc. 2023 Sep 20;13(18):e4825. doi: 10.21769/BioProtoc.4825. eCollection 2023 Sep 20.
PMID: 37753470
Yield of Serial Testing for Tuberculosis Exposure in Patients With Inflammatory Bowel Diseases: One Test is Not Enough.
Lapp SL, Bewtra M, Lewis JD; SPARC IBD Investigators. Clin Gastroenterol Hepatol. 2024 Feb;22(2):420-422.e2. doi: 10.1016/j.cgh.2023.06.003. Epub 2023 Jun 17.
PMID: 37331412
The enteric nervous system relays psychological stress to intestinal inflammation.
Schneider KM, Blank N, Alvarez Y, Thum K, Lundgren P, Litichevskiy L, Sleeman M, Bahnsen K, Kim J, Kardo S, Patel S, Dohnalová L, Uhr GT, Descamps HC, Kircher S, McSween AM, Ardabili AR, Nemec KM, Jimenez MT, Glotfelty LG, Eisenberg JD, Furth EE, Henao-Mejia J, Bennett FC, Pierik MJ, Romberg-Camps M, Mujagic Z, Prinz M, Schneider CV, Wherry EJ, Bewtra M, Heuckeroth RO, Levy M, Thaiss CA. Cell. 2023 Jun 22;186(13):2823-2838.e20. doi: 10.1016/j.cell.2023.05.001. Epub 2023 May 25.
PMID: 37236193
Utilization of Treat-to-Target Monitoring Colonoscopy After Treatment Initiation in the US-Based Study of a Prospective Adult Research Cohort With Inflammatory Bowel Disease.
Yang JY, Lund JL, Funk MJ, Hudgens MG, Lewis JD, Kappelman MD; SPARC IBD Investigators. Am J Gastroenterol. 2023 Sep 1;118(9):1638-1647. doi: 10.14309/ajg.0000000000002294. Epub 2023 Apr 13. PMID: 37053548
Humoral Immune Response and Safety of SARS-CoV-2 Vaccination in Pediatric Inflammatory Bowel Disease.
Kastl AJ, Weaver KN, Zhang X, Strople JA, Adler J, Dubinsky MC, Bousvaros A, Watkins R, Dai X, Chen W, Cross RK, Higgins PDR, Ungaro RC, Bewtra M, Bellaguarda EA, Farraye FA, Chun KY, Zikry M, Fernando M, Bastidas M, Hernandez CG, Craig RG, Boccieri ME, Firestine A, Long MD, Kappelman MD. Am J Gastroenterol. 2023 Jan 1;118(1):129-137. doi: 10.14309/ajg.0000000000002016. Epub 2022 Sep 16.
PMID: 36114773
The miR-181 family regulates colonic inflammation through its activity in the intestinal epithelium. Jimenez MT, Clark ML, Wright JM, Michieletto MF, Liu S, Erickson I, Dohnalova L, Uhr GT, Tello-Cajiao J, Joannas L, Williams A, Gagliani N, Bewtra M, Tomov VT, Thaiss CA, Henao-Mejia J. J Exp Med. 2022 Dec 5;219(12):e20212278. doi: 10.1084/jem.20212278. Epub 2022 Sep 8.
PMID: 36074090
Low Rates of Breakthrough COVID-19 Infection After SARS-CoV-2 Vaccination in Patients With Inflammatory Bowel Disease.
Weaver KN, Zhang X, Dai X, Chen W, Watkins R, Adler J, Dubinsky MC, Kastl A, Bousvaros A, Strople JA, Cross RK, Higgins PDR, Ungaro RC, Bewtra M, Bellaguarda E, Farraye FA, Craig R, Hernandez C, Boccieri ME, Firestine A, Chun KY, Long MD, Kappelman MD. Inflamm Bowel Dis. 2023 Mar 1;29(3):483-486. doi: 10.1093/ibd/izac138.
PMID: 35830416
High-dimensional profiling reveals Tc17 cell enrichment in active Crohn's disease and identifies a potentially targetable signature.
Globig AM, Hipp AV, Otto-Mora P, Heeg M, Mayer LS, Ehl S, Schwacha H, Bewtra M, Tomov V, Thimme R, Hasselblatt P, Bengsch B. Nat Commun. 2022 Jun 27;13(1):3688. doi: 10.1038/s41467-022-31229-z.
PMID: 35760777
Strong Response to SARS-CoV-2 Vaccine Additional Doses Among Patients With Inflammatory Bowel Diseases. Long MD, Weaver KN, Zhang X, Chun K, Kappelman MD; PREVENTCOVID Study Group. Clin Gastroenterol Hepatol. 2022 Aug;20(8):1881-1883.e1. doi: 10.1016/j.cgh.2022.01.056. Epub 2022 Feb 9.
PMID: 35150924
Factors Affecting Initial Humoral Immune Response to SARS-CoV-2 Vaccines Among Patients With Inflammatory Bowel Diseases.
Kappelman MD, Weaver KN, Zhang X, Dai X, Watkins R, Adler J, Dubinsky MC, Kastl A, Bousvaros A, Strople JA, Cross RK, Higgins PDR, Ungaro RC, Bewtra M, Bellaguarda EA, Farraye FA, Boccieri ME, Firestine A, Chun KY, Fernando M, Bastidas M, Zikry M, Long MD. Am J Gastroenterol. 2022 Mar 1;117(3):462-469. doi: 10.14309/ajg.0000000000001619.
PMID: 35029167
Impact of SARS-CoV-2 Vaccination on Inflammatory Bowel Disease Activity and Development of Vaccine-Related Adverse Events: Results From PREVENT-COVID.
Weaver KN, Zhang X, Dai X, Watkins R, Adler J, Dubinsky MC, Kastl A, Bousvaros A, Strople JA, Cross RK, Higgins PDR, Ungaro RC, Bewtra M, Bellaguarda E, Farraye FA, Boccieri ME, Firestine A, Kappelman MD, Long MD. Inflamm Bowel Dis. 2022 Oct 3;28(10):1497-1505. doi: 10.1093/ibd/izab302.
PMID: 34871388
Women's Willingness to Accept Risks of Medication for Inflammatory Bowel Disease During Pregnancy.
Kushner T, Fairchild A, Johnson FR, Sands BE, Mahadevan U, Subramanian S, Ananthakrishnan A, Ha C, Bewtra M. Patient. 2022 May;15(3):353-365. doi: 10.1007/s40271-021-00561-9. Epub 2021 Nov 9. PMID: 34750784
The Development and Initial Findings of A Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease (SPARC IBD).
Raffals LE, Saha S, Bewtra M, Norris C, Dobes A, Heller C, O'Charoen S, Fehlmann T, Sweeney S, Weaver A, Bishu S, Cross R, Dassopoulos T, 9/3/25, 1:00 PM Clipboard - PubMed https://pubmed.ncbi.nlm.nih.gov/clipboard/ 7/14 Fischer M, Yarur A, Hudesman D, Parakkal D, Duerr R, Caldera F, Korzenik J, Pekow J, Wells K, Bohm M, Perera L, Kaur M, Ciorba M, Snapper S, Scoville EA, Dalal S, Wong U, Lewis JD. Inflamm Bowel Dis. 2022 Feb 1;28(2):192-199. doi: 10.1093/ibd/izab071. PMID: 34436563
Humoral Immune Response to Messenger RNA COVID19 Vaccines Among Patients With Inflammatory Bowel Disease.
Kappelman MD, Weaver KN, Boccieri M, Firestine A, Zhang X, Long MD; PREVENT-COVID Study Group. Gastroenterology. 2021 Oct;161(4):1340-1343.e2. doi: 10.1053/j.gastro.2021.06.016. Epub 2021 Jun 15.
PMID: 34144046
The Impact of Introducing Patient-Reported Inflammatory Bowel Disease Symptoms via Electronic Survey on Clinic Visit Length, Patient and Provider Satisfaction, and the Environment Microbiome.
Roy Paladhi U, Harb AH, Daniel SG, Dawwas GK, Schnellinger EM, Wollack C, Aberra FN, Bewtra M, Green JA, Klaproth JA, Lichtenstein GR, Saxena A, Berera S, Buchner A, Mehta SJ, Osterman MT, Rashid F, Tomov V, Caldera F, Sumona S, Mahadevan U, Roy A, Nessel L, Wu GD, Bittinger K, Lewis JD. Inflamm Bowel Dis. 2021 Apr 15;27(5):746-750. doi: 10.1093/ibd/izaa356.
PMID: 33452800
Norovirus-Specific CD8 T Cell Responses in Human Blood and Tissues.
Pattekar A, Mayer LS, Lau CW, Liu C, Palko O, Bewtra M, Consortium H, Lindesmith LC, Brewer-Jensen PD, Baric RS, Betts MR, Naji A, Wherry EJ, Tomov VT. Cell Mol Gastroenterol Hepatol. 2021;11(5):1267-1289. doi: 10.1016/j.jcmgh.2020.12.012. Epub 2021 Jan 11.
PMID: 33444817
Support Tools for Preference-Sensitive Decisions in Healthcare: Where Are We? Where Do We Go? How Do We Get There?
Ostermann J, Brown DS, van Til JA, Bansback N, Légaré F, Marshall DA, Bewtra M. Patient. 2019 Oct;12(5):439-443. doi: 10.1007/s40271-019-00372-z.
PMID: 31256346
Comparing the Noncomparable: The Need for Equivalence Measures That Make Sense in HealthEconomic Evaluations.
Johnson FR, Scott FI, Reed SD, Lewis JD, Bewtra M. Value Health. 2019 Jun;22(6):684-692. doi: 10.1016/j.jval.2019.03.011. Epub 2019 May 17.
PMID: 31198186
Variation Among Patients With Crohn's Disease in Benefit vs Risk Preferences and Remission Time Equivalents.
Bewtra M, Reed SD, Johnson FR, Scott FI, Gilroy E, Sandler RS, Chen W, Lewis JD. Clin Gastroenterol Hepatol. 2020 Feb;18(2):406-414.e7. doi: 10.1016/j.cgh.2019.05.010. Epub 2019 May 14.
PMID: 31100456
Improved Quality of Life With Anti-TNF Therapy Compared With Continued Corticosteroid Utilization in Crohn's Disease. Scott FI, Johnson FR, Bewtra M, Brensinger CM, Roy JA, Reed SD, Osterman MT, Mamtani R, Chen L, Yun H, Xie F, Curtis JR, Lewis JD. Inflamm Bowel Dis. 2019 Apr 11;25(5):925-936. doi: 10.1093/ibd/izy321.
PMID: 30535149
Anti-TNF Drugs versus Long-Term Steroid Use for Patients with Inflammatory Bowel Diseases [Internet].
Lewis JD, Bewtra M, Scott FI, Brensinger CM, Reed SD, Roy JA, Osterman MT, Mamtani R, Chen L, Yun H, Xie F, Gilroy E, Sandler RS, Chen W, Curtis JR, Johnson FR. Washington (DC): Patient-Centered Outcomes Research Institute (PCORI); 2018 Nov.
PMID: 37428852
High-dimensional immune phenotyping and transcriptional analyses reveal robust recovery of viable human immune and epithelial cells from frozen gastrointestinal tissue.
Konnikova L, Boschetti G, Rahman A, Mitsialis V, Lord J, Richmond C, Tomov VT, Gordon W, Jelinsky S, Canavan J, Liss A, Wall S, Field M, Zhou F, Goldsmith JD, Bewtra M, Breault DT, Merad M, Snapper SB. Mucosal Immunol. 2018 Nov;11(6):1684-1693. doi: 10.1038/s41385-018- 0047-y. Epub 2018 Aug 15.
PMID: 30111863
State of Adult Trainee Inflammatory Bowel Disease Education in the United States: A National Survey.
Cohen BL, Ha C, Ananthakrishnan AN, Rieder F, Bewtra M. Inflamm Bowel Dis. 2016 Jul;22(7):1609-15. doi: 10.1097/MIB.0000000000000766.
PMID: 27306068
Rising Educators, Academicians, and Clinicians Helping Inflammatory Bowel Disease (REACH-IBD)-Promoting Improvement of Inflammatory Bowel Disease Education in the United States.
Rieder F, Cohen BL, Dotson JL, Bewtra M, Ananthakrishnan AN, Falaiye TO, Ha CY. Inflamm Bowel Dis. 2016 Jun;22(6):1531-2. doi: 10.1097/MIB.0000000000000814.
PMID: 27167574 Free PMC article.
Patients with Ulcerative Colitis Are More Concerned About Complications of Their Disease than Side Effects of Medications.
Thompson KD, Connor SJ, Walls DM, Gollins J, Stewart SK, Bewtra M, Baumblatt GL, Holubar SD, Greenup AJ, Sechi A, Girgis A, Rubin DT, Siegel CA. Inflamm Bowel Dis. 2016 Apr;22(4):940-7. doi: 10.1097/MIB.0000000000000740.
PMID: 26950308
Inflammatory Bowel Disease Patients' Willingness to Accept Medication Risk to Avoid Future Disease Relapse. Bewtra M, Fairchild AO, Gilroy E, Leiman DA, Kerner C, Johnson FR, Lewis JD. Am J Gastroenterol. 2015 Dec;110(12):1675-81. doi: 10.1038/ajg.2015.321. Epub 2015 Oct 20.
PMID: 26482859
Mortality associated with medical therapy versus elective colectomy in ulcerative colitis: a cohort study.
Bewtra M, Newcomb CW, Wu Q, Chen L, Xie F, Roy JA, Aarons CB, Osterman MT, Forde KA, Curtis JR, Lewis JD. Ann Intern Med. 2015 Aug 18;163(4):262-70. doi: 10.7326/M14-0960.
PMID: 26168366
An optimized patient-reported ulcerative colitis disease activity measure derived from the Mayo Score and the Simple Clinical Colitis Activity Index.
Bewtra M. Inflamm Bowel Dis. 2015 Jan;21(1):E1. doi: 10.1097/MIB.0000000000000256.
PMID: 25479459
The benefit-to-risk balance of combining infliximab with azathioprine varies with age: a markov model.
Scott FI, Vajravelu RK, Bewtra M, Mamtani R, Lee D, Goldberg DS, Lewis JD. Clin Gastroenterol Hepatol. 2015 Feb;13(2):302-309.e11. doi: 10.1016/j.cgh.2014.07.058. Epub 2014 Aug 10.
PMID: 25117775
An optimized patient-reported ulcerative colitis disease activity measure derived from the Mayo score and the simple clinical colitis activity index.
Bewtra M, Brensinger CM, Tomov VT, Hoang TB, Sokach CE, Siegel CA, Lewis JD. Inflamm Bowel Dis. 2014 Jun;20(6):1070-8. doi: 10.1097/MIB.0000000000000053.
PMID: 24810138
Patient preferences for surgical versus medical therapy for ulcerative colitis.
Bewtra M, Kilambi V, Fairchild AO, Siegel CA, Lewis JD, Johnson FR. Inflamm Bowel Dis. 2014 Jan;20(1):103-14. doi: 10.1097/01.MIB.0000437498.14804.50.
PMID: 24280881
Histone deacetylase 3 coordinates commensal-bacteriadependent intestinal homeostasis.
Alenghat T, Osborne LC, Saenz SA, Kobuley D, Ziegler CG, Mullican SE, Choi I, Grunberg S, Sinha R, Wynosky-Dolfi M, Snyder A, Giacomin PR, Joyce KL, Hoang TB, Bewtra M, Brodsky IE, Sonnenberg GF, Bushman FD, Won KJ, Lazar MA, Artis D. Nature. 2013 Dec 5;504(7478):153-7. doi: 10.1038/nature12687. Epub 2013 Nov 3.
PMID: 24185009
Assessing patient preferences for treatment options and process of care in inflammatory bowel disease: a critical review of quantitative data.
Bewtra M, Johnson FR. Patient. 2013;6(4):241-55. doi: 10.1007/s40271-013-0031-2.
PMID: 24127239
Crohn's disease and ulcerative colitis are associated with elevated standardized mortality ratios: a meta-analysis. Bewtra M, Kaiser LM, TenHave T, Lewis JD. Inflamm Bowel Dis. 2013 Mar;19(3):599-613. doi: 10.1097/MIB.0b013e31827f27ae.
PMID: 23388544
Trends in hospitalization rates for inflammatory bowel disease in the United States. Bewtra M, Su C, Lewis JD. Clin Gastroenterol Hepatol. 2007 May;5(5):597-601. doi: 10.1016/j.cgh.2007.01.015. Epub 2007 Mar 26.
PMID: 17382602
PUBLICATIONS AND AWARDS
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Awards won by members of our research team:
E. John Wherry: Innovation in Collaboration Award Dr. Bewtra won the Doctors of America Founders Award for Excellence in Advocacy (2022) ' Our team has published some of our findings: IBD Patients' Willingness to Accept Medication Risk to Avoid Future Disease Relapse. Bewtra M, Fairchild AO, Gilroy E, Leiman DA, Kerner C, Johnson FR, Lewis JD. Am J Gastroenterol. 2015 Dec;110(12):1675-81. doi: 10.1038/ajg.2015.321. Epub 2015 Oct 20. PMID:26482859 An optimized patient-reported ulcerative colitis disease activity measure derived from the Mayo score and the simple clinical colitis activity index. Bewtra M, Brensinger CM, Tomov VT, Hoang TB, Sokach CE, Siegel CA, Lewis JD. Inflamm Bowel Dis. 2014 Jun;20(6):1070-8. doi: 10.1097/MIB.0000000000000053. PMID:24810138 Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis. Alenghat T, Osborne LC, Saenz SA, Kobuley D, Ziegler CG, Mullican SE, Choi I, Grunberg S, Sinha R, Wynosky-Dolfi M, Snyder A, Giacomin PR, Joyce KL, Hoang TB, Bewtra M, Brodsky IE, Sonnenberg GF, Bushman FD, Won KJ, Lazar MA, Artis D. Nature. 2013 Dec 5;504(7478):153-7. doi: 10.1038/nature12687. Epub 2013 Nov 3. PMID:24185009 Differentiation and Protective Capacity of Virus-Specific CD8+ T Cells Suggest Murine Norovirus Persistence in an Immune-Privileged Enteric Niche Tomov VT, Palko O, Lau CW, Pattekar A, Sun Y, Tacheva R, Bengsch B, Manne S, Cosma GL, Eisenlohr LC, Nice TJ, Virgin HW, Wherry EJ. 2017 Oct17;47(4):723-738.e5. doi: 10.1016/j.immuni.2017.09.017. Epub 2017 Oct 11. PMID: 29031786 Gut microbiota and IBD: causation or correlation? Ni J, Wu GD, Albenberg L, Tomov VT. Nat Rev Gastroenterol Hepatol. 2017 Oct;14(10):573-584. doi: 10.1038/nrgastro.2017.88. Epub 2017 Jul 19. PMID: 28743984 High-dimensional immune phenotyping and transcriptional analyses reveal robust recovery of viable human immune and epithelial cells from frozen gastrointestinal tissue. Konnikova L, Boschetti G, Rahman A, Mitsialis V, Lord J, Richmond C, Tomov VT, Gordon W, Jelinsky S, Canavan J, Liss A, Wall S, Field M, Zhou F, Goldsmith JD, Bewtra M, Breault DT, Merad M, Snapper SB. Mucosal Immunol. 2018. Nov;11(6):1684-1693. doi: 10.1038/s41385-018-0047-y. Epub 2018 Aug 15. PMID: 30111863 The miR-181 family regulates colonic inflammation through its activity in the intestinal epithelium Monica T. Jimenez, Megan L. Clark, Jasmine M. Wright, Michaël F. Michieletto, Suying Liu, Isabel Erickson, Lenka Dohnalova, Giulia T. Uhr, John Tello-Cajiao, Leonel Joannas, Adam Williams, Nicola Gagliani, Meenakshi Bewtra,Vesselin T. Tomov,Christoph A. Thaiss,Jorge Henao-Mejia J Exp Med 2022 Dec 5;219(12):e20212278. doi: 10.1084/jem.20212278. Epub 2022 Sep 8. PMID: 36074090 High-dimensional profiling reveals Tc17 cell enrichment in active Crohn’s disease and identifies a potentially targetable signature A-M Globig, A V Hipp, P Otto-Mora, M Heeg, L S Mayer, S Ehl, H Schwacha, M Bewtra, V Tomov, R Thimme, P Hasselblatt, B Bengsch Nat Commun. 2022 Jun 27;13(1):3688.doi: 10.1038/s41467-022-31229-z. PMID: 35760777 The enteric nervous system relays psychological stress to intestinal inflwww.cell.com/cell/fulltext/S0092-8674(23)00475-0ammation Kai Markus Schneider, Niklas Blank, Yelina Alvarez, Robert O. Heuckeroth, Maayan Levy, Christoph A. Thaiss |
Surgeon General for Doctors for America w/ Dr. Bewtra
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SPECIAL THANK YOU TO ALL I3 Participants
We want to thank ALL of the patients in the I3 study, and especially those who volunteered to participate in the stress study. This important work was published in Cell and uncovered a brain-gut pathway that showed that psychological stress worsens intestinal inflammation and dysmotility in both UC and Crohn's disease. These findings would not have been possible without patients like you! Please stay tuned for more updates; thank you again!
We want to thank ALL of the patients in the I3 study, and especially those who volunteered to participate in the stress study. This important work was published in Cell and uncovered a brain-gut pathway that showed that psychological stress worsens intestinal inflammation and dysmotility in both UC and Crohn's disease. These findings would not have been possible without patients like you! Please stay tuned for more updates; thank you again!