PUBLICATIONS AND AWARDS
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Awards won by members of our research team:
E. John Wherry: Innovation in Collaboration Award Dr. Bewtra won the Doctors of America Founders Award for Excellence in Advocacy (2022) ' Our team has published some of our findings: IBD Patients' Willingness to Accept Medication Risk to Avoid Future Disease Relapse. Bewtra M, Fairchild AO, Gilroy E, Leiman DA, Kerner C, Johnson FR, Lewis JD. Am J Gastroenterol. 2015 Dec;110(12):1675-81. doi: 10.1038/ajg.2015.321. Epub 2015 Oct 20. PMID:26482859 An optimized patient-reported ulcerative colitis disease activity measure derived from the Mayo score and the simple clinical colitis activity index. Bewtra M, Brensinger CM, Tomov VT, Hoang TB, Sokach CE, Siegel CA, Lewis JD. Inflamm Bowel Dis. 2014 Jun;20(6):1070-8. doi: 10.1097/MIB.0000000000000053. PMID:24810138 Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis. Alenghat T, Osborne LC, Saenz SA, Kobuley D, Ziegler CG, Mullican SE, Choi I, Grunberg S, Sinha R, Wynosky-Dolfi M, Snyder A, Giacomin PR, Joyce KL, Hoang TB, Bewtra M, Brodsky IE, Sonnenberg GF, Bushman FD, Won KJ, Lazar MA, Artis D. Nature. 2013 Dec 5;504(7478):153-7. doi: 10.1038/nature12687. Epub 2013 Nov 3. PMID:24185009 Differentiation and Protective Capacity of Virus-Specific CD8+ T Cells Suggest Murine Norovirus Persistence in an Immune-Privileged Enteric Niche Tomov VT, Palko O, Lau CW, Pattekar A, Sun Y, Tacheva R, Bengsch B, Manne S, Cosma GL, Eisenlohr LC, Nice TJ, Virgin HW, Wherry EJ. 2017 Oct17;47(4):723-738.e5. doi: 10.1016/j.immuni.2017.09.017. Epub 2017 Oct 11. PMID: 29031786 Gut microbiota and IBD: causation or correlation? Ni J, Wu GD, Albenberg L, Tomov VT. Nat Rev Gastroenterol Hepatol. 2017 Oct;14(10):573-584. doi: 10.1038/nrgastro.2017.88. Epub 2017 Jul 19. PMID: 28743984 High-dimensional immune phenotyping and transcriptional analyses reveal robust recovery of viable human immune and epithelial cells from frozen gastrointestinal tissue. Konnikova L, Boschetti G, Rahman A, Mitsialis V, Lord J, Richmond C, Tomov VT, Gordon W, Jelinsky S, Canavan J, Liss A, Wall S, Field M, Zhou F, Goldsmith JD, Bewtra M, Breault DT, Merad M, Snapper SB. Mucosal Immunol. 2018. Nov;11(6):1684-1693. doi: 10.1038/s41385-018-0047-y. Epub 2018 Aug 15. PMID: 30111863 The miR-181 family regulates colonic inflammation through its activity in the intestinal epithelium Monica T. Jimenez, Megan L. Clark, Jasmine M. Wright, Michaël F. Michieletto, Suying Liu, Isabel Erickson, Lenka Dohnalova, Giulia T. Uhr, John Tello-Cajiao, Leonel Joannas, Adam Williams, Nicola Gagliani, Meenakshi Bewtra,Vesselin T. Tomov,Christoph A. Thaiss,Jorge Henao-Mejia J Exp Med 2022 Dec 5;219(12):e20212278. doi: 10.1084/jem.20212278. Epub 2022 Sep 8. PMID: 36074090 High-dimensional profiling reveals Tc17 cell enrichment in active Crohn’s disease and identifies a potentially targetable signature A-M Globig, A V Hipp, P Otto-Mora, M Heeg, L S Mayer, S Ehl, H Schwacha, M Bewtra, V Tomov, R Thimme, P Hasselblatt, B Bengsch Nat Commun. 2022 Jun 27;13(1):3688.doi: 10.1038/s41467-022-31229-z. PMID: 35760777 The enteric nervous system relays psychological stress to intestinal inflwww.cell.com/cell/fulltext/S0092-8674(23)00475-0ammation Kai Markus Schneider, Niklas Blank, Yelina Alvarez, Robert O. Heuckeroth, Maayan Levy, Christoph A. Thaiss |
Surgeon General for Doctors for America w/ Dr. Bewtra
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SPECIAL THANK YOU TO ALL I3 Participants
We want to thank ALL of the patients in the I3 study, and especially those who volunteered to participate in the stress study. This important work was published in Cell and uncovered a brain-gut pathway that showed that psychological stress worsens intestinal inflammation and dysmotility in both UC and Crohn's disease. These findings would not have been possible without patients like you! Please stay tuned for more updates; thank you again!
We want to thank ALL of the patients in the I3 study, and especially those who volunteered to participate in the stress study. This important work was published in Cell and uncovered a brain-gut pathway that showed that psychological stress worsens intestinal inflammation and dysmotility in both UC and Crohn's disease. These findings would not have been possible without patients like you! Please stay tuned for more updates; thank you again!